Back to search

Article

Metabolic control of drug resistance by a mycobacterial ion channel

2026-03-10

Abstract excerpt

<h4>ABSTRACT</h4> Pyrazinamide (PZA) is a cornerstone of modern tuberculosis therapy, yet its context-dependent activity has obscured both its mode of action and resistance mechanisms. Using a host-mimicking culture system integrated with genome-wide CRISPRi profiling, metabolomics, and comparative genomics, we identify a previously unrecognized driver of PZA resistance in humans: loss of the ion channel Rv2571c....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
224a1486-53b0-522a-88c6-74426de74f1c
DOI
10.64898/2026.03.10.710584
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Metabolic control of drug resistance by a mycobacterial ion channelDOI 10.64898/2026.03.10.710584
Deciphering the transcriptomic landscape of pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity
The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.Semantic proximity
<i>α</i> -Aminooxyacetic acid derivatives acting as pro-drugs against <i>Mycobacterium tuberculosis</i>Semantic proximity
Visualizing pyrazinamide action by live single cell imaging of phagosome acidification and <i>Mycobacterium tuberculosis</i> pH homeostasisSemantic proximity
The phenotypic landscape of the mycobacterial cellSemantic proximity
KatG inactivation generates vulnerabilities in isoniazid resistant strains of <i>Mycobacterium tuberculosis</i>Semantic proximity
Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis.Semantic proximity
Comparative transcriptomic profiling of pyrazinamide resistance in Mycobacterium tuberculosis.Semantic proximity
A chemical-genetic map of the pathways controlling drug potency in <i>Mycobacterium tuberculosis</i>Semantic proximity
Mycobacterium smegmatis msmeg_3314 is involved in pyrazinamide and fluoroquinolones susceptibility via NAD+/NADH dysregulation.Semantic proximity
Beyond antibiotic resistance: the <i>whiB7</i> transcription factor coordinates an adaptive response to alanine starvation in mycobacteriaSemantic proximity
A multiplexed, target-based phenotypic screening platform using CRISPR interference in <i>Mycobacterium abscessus</i>Semantic proximity
Select a neighboring publication to make it the new centre.