Article

The pH gradient contributes to persistence in Mycobacterium tuberculosis

2025-09-15

Abstract excerpt

<title>Abstract</title> <p>Tuberculosis (TB) remains difficult to cure due in part to poorly defined drug-tolerant persister cells formed by <italic>Mycobacterium tuberculosis</italic> (Mtb), which survive antibiotic treatment without evidence of genetic resistance. To better define this phenotype, we screened 2,336 FDA-approved drugs for compounds that target persistence. Unexpectedly, we identified a strong ind...

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Literature Corpus work: c74456aa-0e01-567f-af0f-c18a5d34430a
DOI: 10.21203/rs.3.rs-7466214/v1

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