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Article

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide.

Nature communications - 21 Jun 2021

Santucci Pierre, Greenwood Daniel J, Fearns Antony, Chen Kai, Jiang Haibo, Gutierrez Maximiliano G

Abstract excerpt

To be effective, chemotherapy against tuberculosis (TB) must kill the intracellular population of the pathogen, Mycobacterium tuberculosis. However, how host cell microenvironments affect antibiotic accumulation and efficacy remains unclear. Here, we use correlative light, electron, and ion microscopy to investigate how various microenvironments within human macrophages affect the activity of pyrazinamide (PZA),...

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Identifiers

PMID: 34155215
DOI: 10.1038/s41467-021-24127-3
PMCID: PMC8217510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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