Potassium response and homeostasis in Mycobacterium tuberculosis modulates environmental adaptation and is important for host colonization

Abstract excerpt

Successful host colonization by bacteria requires sensing and response to the local ionic milieu, and coordination of responses with the maintenance of ionic homeostasis in the face of changing conditions.We previously discovered that Mycobacterium tuberculosis (Mtb) responds synergistically to chloride (Cl -) and pH, as cues to the immune status of its host.This raised the intriguing concept of abundant ions as...

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