Article

Anti-tubercular potential and pH-driven mode of action of salicylic acid derivatives

2024-09-22

Abstract excerpt

In the search for new anti-tuberculosis drugs with novel mechanisms of action, we evaluated the antimycobacterial activity of a panel of eight phenolic acids against four pathogenic mycobacterial model species, including M. tuberculosis . We demonstrated that salicylic acid ( SA ), as well as the iodinated derivatives 5-iodo-salicylic acid ( 5ISA ) and 3,5-diiodo-salicylic acid ( 3,5diISA ), displayed promisin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1290caf-5caf-54e9-a2ae-acd9ffbd4301
DOI: 10.1101/2024.09.22.614344

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anti-tubercular potential and pH-driven mode of action of salicylic acid derivativesDOI 10.1101/2024.09.22.614344Read

Visualizing pyrazinamide action by live single cell imaging of phagosome acidification and <i>Mycobacterium tuberculosis</i> pH homeostasisSemantic proximity Read

Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.Semantic proximity Read

Phagosomal acidification coordinates a lipid–redox program underlying antibiotic tolerance in Mycobacterium tuberculosisSemantic proximity Read

Potassium response and homeostasis in Mycobacterium tuberculosis modulates environmental adaptation and is important for host colonizationSemantic proximity Read

A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.Semantic proximity Read

Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of Mycobacterium tuberculosis in Macrophages.Semantic proximity Read

C-Terminal Domain of <i>Mycobacterium tuberculosis</i> Glutamate Decarboxylase determines the bacterial stress-adaptive metabolic state that steers macrophage polarisation supporting intracellular persistenceSemantic proximity Read

<i>Mycobacterium tuberculosis</i> sulfolipid-1 (Sl-1) increases the excitability of mouse and human TRPV1-positive sensory neurons in a YM254890-reversible fashionSemantic proximity Read

Anti-cancer drug Tamoxifen interferes with <i>Mycobacterium tuberculosis</i> PhoPR mediated signaling and inhibits mycobacterial growthSemantic proximity Read

Synthesis and Analysis of Bacterial Folate Metabolism Intermediates and Antifolates.Semantic proximity Read

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide.Semantic proximity Read

Measurement of Small Molecule Accumulation into Diderm BacteriaSemantic proximity Read