Article

The pH gradient contributes to persistence in <i>Mycobacterium tuberculosis</i>

2025-09-12

Abstract excerpt

Tuberculosis (TB) remains difficult to cure due in part to poorly defined drug-tolerant persister cells formed by Mycobacterium tuberculosis (Mtb), which survive antibiotic treatment without evidence of genetic resistance. To better define this phenotype, we screened 2,336 FDA-approved drugs for compounds that target persistence. Unexpectedly, we identified a strong inducer of drug tolerance -- the antiparasitic...

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Literature Corpus work: 395f25a1-7dc5-5c61-9d57-cc03e7b12b45
DOI: 10.1101/2025.09.12.675885

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