Article
Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2005
Park Jaehong, Hu Yanhui, Murthy T V S, Vannberg Fredrik, Shen Binghua, Rolfs Andreas, Hutti Jessica E, Cantley Lewis C, Labaer Joshua, Harlow Ed, Brizuela Leonardo
Abstract excerpt
Kinases catalyze the phosphorylation of proteins, lipids, sugars, nucleosides, and other important cellular metabolites and play key regulatory roles in all aspects of eukaryotic cell physiology. Here, we describe the mining of public databases to collect the sequence information of all identified human kinase genes and the cloning of the corresponding ORFs. We identified 663 genes, 511 encoding protein kinases,...
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