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Article

High yield bacterial expression of active c‐Abl and c‐Src tyrosine kinases

1 Nov 2005

Abstract excerpt

The Abl and Src tyrosine kinases are key signaling proteins that are of considerable interest as drug targets in cancer and many other diseases. The regulatory mechanisms that control the activity of these proteins are complex, and involve large-scale conformational changes in response to phosphorylation and other modulatory signals. The success of the Abl inhibitor imatinib in the treatment of chronic...

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PMID: 16260764
DOI: 10.1110/ps.051750905

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