Article

Altered hippocampal activation in seizure-prone <i>CACNA2D2</i> knockout mice

2023-11-10

Abstract excerpt

The voltage-gated calcium channel subunit α2δ-2 controls calcium-dependent signaling in neurons, and loss of this subunit causes epilepsy in both mice and humans. To determine whether mice without α2δ-2 demonstrate hippocampal activation or histopathological changes associated with seizure activity, we measured expression of the activity-dependent gene c-fos and various histopathological correlates of temporal lo...

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Literature Corpus work: 120219db-cc5e-5db2-88c7-74b415cc20bd
DOI: 10.1101/2023.11.08.565511

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