Article

GluK2 is a target for gene therapy in drug-resistant Temporal Lobe Epilepsy

2023-04-13

Abstract excerpt

<h4>Objective</h4> Temporal lobe epilepsy (TLE) is characterized by recurrent seizures generated in the limbic system, particularly in the hippocampus. In TLE, recurrent mossy fiber sprouting from dentate gyrus granule cells (DGCs) creates an aberrant epileptogenic network between DGCs which operates via ectopically expressed GluK2/GluK5-containing kainate receptors (KARs). TLE patients are often resistant to ant...

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Literature Corpus work: 603c44f1-540b-512f-abb6-8b092de8f623
DOI: 10.1101/2023.04.13.536748

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