Article

<i>Fam72a</i> controls the balance between error-prone and error-free DNA repair during antibody diversification

2020-12-23

Abstract excerpt

Efficient humoral responses rely on DNA damage, mutagenesis and error-prone DNA repair. B cell receptor diversification through somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by cytidine deamination in DNA mediated by activation induced cytidine deaminase (AID) 1 and by the subsequent excision of the resulting uracils by Uracil DNA glycosylase (UNG) and by mismatch repair (MMR) pro...

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Identifiers and source

Literature Corpus work: 240316ae-f99b-5ada-b4f8-73c624f5b065
DOI: 10.1101/2020.12.22.424012

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