Article
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.
Nature - 1 Dec 2021
Feng Yuqing, Li Conglei, Stewart Jessica A, Barbulescu Philip, Seija Desivo Noé, Álvarez-Quilón Alejandro, Pezo Rossanna C, Perera Madusha L W, Chan Katherine, Tong Amy Hin Yan, Mohamad-Ramshan Rukshana, Berru Maribel, Nakib Diana, Li Gavin, Kardar Gholam Ali, Carlyle James R, Moffat Jason, Durocher Daniel, Di Noia Javier M, Bhagwat Ashok S, Martin Alberto
Abstract excerpt
Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination1,2. AID-generated deoxyuracils are recognized and processed by subverted base-excision and mismatch repair pathways that ensure a mutagenic outcome in B cells3-6. However, why these DNA repair pathways do not accurately...
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