Article
Fam72a enforces error-prone DNA repair during antibody diversification.
Nature - 1 Dec 2021
Rogier Mélanie, Moritz Jacques, Robert Isabelle, Lescale Chloé, Heyer Vincent, Abello Arthur, Martin Ophélie, Capitani Katia, Thomas Morgane, Thomas-Claudepierre Anne-Sophie, Laffleur Brice, Jouan Florence, Pinaud Eric, Tarte Karin, Cogné Michel, Conticello Silvestro G, Soutoglou Evi, Deriano Ludovic, Reina-San-Martin Bernardo
Abstract excerpt
Efficient humoral responses rely on DNA damage, mutagenesis and error-prone DNA repair. Diversification of B cell receptors through somatic hypermutation and class-switch recombination are initiated by cytidine deamination in DNA mediated by activation-induced cytidine deaminase (AID)1 and by the subsequent excision of the resulting uracils by uracil DNA glycosylase (UNG) and by mismatch repair proteins1-3....
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