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Article

Immunoglobulin somatic hypermutation.

Annual review of genetics - 1 Jan 2007

Teng Grace, Papavasiliou F Nina

Abstract excerpt

The immunoglobulin (Ig) repertoire achieves functional diversification through several somatic alterations of the Ig locus. One of these processes, somatic hypermutation (SHM), deposits point mutations into the variable region of the Ig gene to generate higher-affinity variants. Activation-induced cytidine deaminase (AID) converts cytidine to uridine to initiate the hypermutation process. Error-prone versions of...

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Identifiers

PMID: 17576170
DOI: 10.1146/annurev.genet.41.110306.130340

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