Article

FAM72A antagonizes UNG2 to promote mutagenic uracil repair during antibody maturation

2020-12-23

Abstract excerpt

Activation-induced cytidine deaminase (AID) catalyzes the deamination of deoxycytidines within Immunoglobulin ( Ig ) genes to induce somatic hypermutation (SHM) and class switch recombination (CSR) 1,2 . AID-induced deoxyuracils within Ig loci are recognized and processed by subverted base excision and mismatch repair pathways that ensure a mutagenic outcome in B lymphocytes 3–8 . However, it is unclear why D...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0cd8e2b4-d8d6-5dd1-9217-8a68adef8b00
DOI: 10.1101/2020.12.23.423975

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FAM72A antagonizes UNG2 to promote mutagenic uracil repair during antibody maturationDOI 10.1101/2020.12.23.423975Read

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.Semantic proximity Read

<i>Fam72a</i> controls the balance between error-prone and error-free DNA repair during antibody diversificationSemantic proximity Read

Fam72a enforces error-prone DNA repair during antibody diversification.Semantic proximity Read

AID in Antibody Diversification: There and Back Again.Semantic proximity Read

UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read

A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets.Semantic proximity Read

Mismatch-mediated error prone repair at the immunoglobulin genes.Semantic proximity Read

Mutating for Good: DNA Damage Responses During Somatic HypermutationSemantic proximity Read

Molecular mechanisms of antibody somatic hypermutation.Semantic proximity Read

AIDing antibody diversity by error-prone mismatch repair.Semantic proximity Read

A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.Semantic proximity Read

MKLN1-dependent GID4/CTLH E3 ubiquitin ligase complex assemblies are required to support B-cell antibody diversificationSemantic proximity Read