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Article

Somatic hypermutation: subverted DNA repair.

Current opinion in immunology - 1 Jun 2006

Martomo Stella A, Gearhart Patricia J

Abstract excerpt

Somatic hypermutation generates high-affinity antibodies of different isotypes that efficiently protect us against a plethora of pathogens. Recent analyses of the types of mutations produced in gene-deficient mice have indicated how DNA repair proteins are drawn into the pathway. Activation-induced cytosine deaminase begins the process by deaminating cytosine to uracil in DNA. The uracils are then recognized by...

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Source

Identifiers

PMID: 16616477
DOI: 10.1016/j.coi.2006.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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