Article

Development of a Novel Single Cell Multiomics Approach for Simultaneous Analysis of Replication Timing and Gene Expression

2025-01-03

Abstract excerpt

Replication timing (RT) allows us to analyze temporal patterns of genome-wide replication, i.e., if genes replicate early or late during the S-phase of the cell cycle. RT has been linked to gene expression in normal and diseased acute and chronic states such as cancer. However, studies done to date focused on bulk cell populations that required tens of thousands of cells for RT analysis. Here, we developed an affo...

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Literature Corpus work: 4b4f1856-65ee-5ef6-944d-c29ed4413a42
DOI: 10.1101/2025.01.02.631160

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