Article

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for <i>TNF</i> mRNA m6A modification

2024-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Macrophages adopt dynamic cell states with distinct effector functions to maintain tissue homeostasis and respond to environmental challenges. During chronic inflammation, macrophage polarization is subverted towards sustained inflammatory states which contribute to disease, but there is limited understanding of the regulatory mechanisms underlying these disease-associated states. Here, we descr...

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Literature Corpus work: 235e9116-5210-58c4-b7a5-7433c9532bd9
DOI: 10.1101/2024.04.12.589122

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Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for <i>TNF</i> mRNA m6A modificationDOI 10.1101/2024.04.12.589122Read

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