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Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon <i>S. aureus</i> infection

2021-10-19

Abstract excerpt

Macrophages are driven to form distinct functional phenotypes in response to different immunological stimuli, in a process widely referred to as macrophage polarization. Transcriptional regulators that guide macrophage polarization in response to a given trigger remain largely unknown. In this study, we interrogate the programmable landscape in macrophages to find regulatory panels that determine the precise polar...

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Literature Corpus work
9a167527-04d6-59b3-b212-9d1042e7692f
DOI
10.1101/2021.10.19.464946
Open publication

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Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon <i>S. aureus</i> infectionDOI 10.1101/2021.10.19.464946
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