Article

Public-Data Reanalysis Links MS4A4A to M2-like Human Myeloid States and Supports a Predicted Four-Pass Transmembrane Fold

2026-08-24

Abstract excerpt

<h4>Background: </h4> /Objectives: MS4A4A is associated with M2-like macrophage states, while the MS4A gene cluster modifies soluble TREM2 levels and Alzheimer's disease risk. We asked whether MS4A4A consistently marks the M2 side of human myeloid activation and whether AlphaFold supports a proposed MS4A4A-MS4A6A interaction. <h4>Methods:</h4> We reanalysed four public human datasets: bulk RNA-seq and ATAC-seq of...

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Literature Corpus work: c72296ad-6f3e-5888-b641-687075cbafe5
DOI: 10.64898/2026.08.19.745820

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Public-Data Reanalysis Links MS4A4A to M2-like Human Myeloid States and Supports a Predicted Four-Pass Transmembrane FoldDOI 10.64898/2026.08.19.745820Read

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