Article

RNA editing enzyme APOBEC3A promotes pro-inflammatory (M1) macrophage polarization

2020-03-22

Abstract excerpt

Pro-inflammatory (M1) macrophage polarization is associated with microbicidal and antitumor responses. We recently described APOBEC3A-mediated cytosine-to-uracil (C>U) RNA editing during M1 polarization. However, the functional significance of this editing is unknown. Here, we find that APOBEC3A-mediated cellular RNA editing can also be induced by influenza or Maraba virus infections of normal human macrophages, a...

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Literature Corpus work: b8bd2e57-1a3c-5319-a9ba-1f4a29a075f5
DOI: 10.1101/2020.03.20.988980

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