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A CROP-seq screen of histone modifying enzymes reveals histone demethylase Kdm5c regulates inflammatory macrophage activation

2025-10-31

Abstract excerpt

<h4>Background</h4> Macrophages adopt activation states along a spectrum from pro- to anti-inflammatory, enabling appropriate responses to pathogens and environmental cues. Dysregulated inflammatory macrophage activation contributes to diseases including sepsis, rheumatoid arthritis, cancer, and atherosclerosis. Epigenetic processes such as DNA methylation and histone modification prime macrophages for activation...

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Literature Corpus work
98e2c221-0a83-535a-9d28-91b746133874
DOI
10.1101/2025.10.30.685537
Open publication

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A CROP-seq screen of histone modifying enzymes reveals histone demethylase Kdm5c regulates inflammatory macrophage activationDOI 10.1101/2025.10.30.685537
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