Article

Uncovering the Gene Regulatory Networks Underlying Macrophage Polarization Through Comparative Analysis of Bulk and Single-Cell Data

2021-01-21

Abstract excerpt

<h4>Summary</h4> Gene regulatory networks (GRNs) provide a powerful framework for studying cellular differentiation. However, it is less clear how GRNs encode cellular responses to everyday microenvironmental cues. Macrophages can be polarized and potentially repolarized based on environmental signaling. In order to identify the GRNs that drive macrophage polarization and the heterogeneous single-cell subpopulati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f76559a-a826-5cfb-bfb3-f98e8a861814
DOI: 10.1101/2021.01.20.427499

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Uncovering the Gene Regulatory Networks Underlying Macrophage Polarization Through Comparative Analysis of Bulk and Single-Cell DataDOI 10.1101/2021.01.20.427499Read

Leveraging a Comprehensive Unbiased RNAseq Database Uncovers New Human Monocyte-Derived Macrophage Subtypes Within Commonly Employed In Vitro Polarization MethodsSemantic proximity Read

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage ActivationSemantic proximity Read

Getting everyone to agree on gene signatures for murine macrophage polarization in vitro.Semantic proximity Read

Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune diseaseSemantic proximity Read

Redefining inflammatory macrophage phenotypes across stages and tissues by single-cell transcriptomics.Semantic proximity Read

Machine Learning Identifies Signatures of Macrophage Reactivity and Tolerance that Predict Disease OutcomesSemantic proximity Read

Trajectory analysis quantifies transcriptional plasticity during macrophage polarization.Semantic proximity Read

Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon <i>S. aureus</i> infectionSemantic proximity Read

Spatiotemporal single cell transcriptomic analysis of human gut macrophages reveals multiple functional and niche-specific subsetsSemantic proximity Read

Automated identification of cell-type–specific genes and alternative promotersSemantic proximity Read

Tissue signatures of human macrophages during homeostasis and activationSemantic proximity Read

Single cell transcriptome analysis of decidua macrophages in normal and recurrent spontaneous abortion patientsSemantic proximity Read