Article
Disruption of macrophage migration inhibitory factor signaling induces major tumor-associated macrophage phenotypes in human M2 macrophages.
Molecular biomedicine - 17 Jul 2026
Klaver Dominik, Gander Hubert, Frena Beatrice, Martin Michael, Amato Marco, Richter Julia, Pichler Renate, Thurnher Martin
Abstract excerpt
Tumor-associated macrophages (TAMs) primarily arise from infiltrating monocytes, yet the mechanisms guiding their differentiation remain unclear. Here, we show that human macrophages rely on autocrine macrophage migration inhibitory factor signaling to suppress p53 during M2-like transition. Disruption of this pathway led to activation of p53 and, unexpectedly, the nuclear receptor NR4A1, inducing a...
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