Article

Sensitive Transcriptomics and Genotyping reveals function of genetic variants in immunity

2025-03-14

Abstract excerpt

Advancements in genomics have revolutionized human genetics by defining the genetic architecture of disease. However, identifying causal variants and their mechanisms of action remains a challenge in translating genetics into therapeutic interventions. Here, we developed Sensitive Transcriptomics And Genotyping by sequencing (STAG-seq), a high-throughput platform designed to define mechanistic genotype-phenotype r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e05b010-a97e-572a-bb0a-029a2366103a
DOI: 10.1101/2025.03.12.642879

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sensitive Transcriptomics and Genotyping reveals function of genetic variants in immunityDOI 10.1101/2025.03.12.642879Read

Defining the function of disease variants with CRISPR editing and multimodal single cell sequencingSemantic proximity Read

Precisely defining disease variant effects in CRISPR-edited single cells.Semantic proximity Read

Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cellsSemantic proximity Read

Genetic and epigenetic fine mapping of causal autoimmune disease variants.Semantic proximity Read

Population-scale multiome immune cell atlas reveals complex disease driversSemantic proximity Read

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screensSemantic proximity Read

Genotype-phenotype correlations in autoimmune and autoinflammatory diseases: An NGS-based immunogenetic cohort study.Semantic proximity Read

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease.Semantic proximity Read

Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases.Semantic proximity Read

Functional phenotyping of genomic variants using multiomic scDNA-scRNA-seqSemantic proximity Read

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infectionSemantic proximity Read

Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cellsSemantic proximity Read