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Article

Hotspots of De Novo Point Mutations in Induced Pluripotent Stem Cells.

Cell reports - 10 Oct 2017

Yoshihara Masahito, Araki Ryoko, Kasama Yasuji, Sunayama Misato, Abe Masumi, Nishida Kohji, Kawaji Hideya, Hayashizaki Yoshihide, Murakawa Yasuhiro

Abstract excerpt

Induced pluripotent stem cells (iPSCs) are generated by direct reprogramming of somatic cells and hold great promise for novel therapies. However, several studies have reported genetic variations in iPSC genomes. Here, we investigated point mutations identified by whole-genome sequencing in mouse and human iPSCs in the context of epigenetic status. In contrast to disease-causing single-nucleotide polymorphisms,...

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Identifiers

PMID: 29020618
DOI: 10.1016/j.celrep.2017.09.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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