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Article

iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2017

Kwon Erika M, Connelly John P, Hansen Nancy F, Donovan Frank X, Winkler Thomas, Davis Brian W, Alkadi Halah, Chandrasekharappa Settara C, Dunbar Cynthia E, Mullikin James C, Liu Paul

Abstract excerpt

Genome integrity of induced pluripotent stem cells (iPSCs) has been extensively studied in recent years, but it is still unclear whether iPSCs contain more genomic variations than cultured somatic cells. One important question is the origin of genomic variations detected in iPSCs-whether iPSC reprogramming induces such variations. Here, we undertook a unique approach by deriving fibroblast subclones and clonal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28167771
DOI: 10.1073/pnas.1616035114
PMCID: PMC5338363

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