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Article

Higher-order genome organization in human disease.

Cold Spring Harbor perspectives in biology - 1 Aug 2010

Misteli Tom

Abstract excerpt

Genomes are organized into complex higher-order structures by folding of the DNA into chromatin fibers, chromosome domains, and ultimately chromosomes. The higher-order organization of genomes is functionally important for gene regulation and control of gene expression programs. Defects in how chromatin is globally organized are relevant for physiological and pathological processes. Mutations and transcriptional...

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Identifiers

PMID: 20591991
DOI: 10.1101/cshperspect.a000794
PMCID: PMC2908770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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