Article

Molecular dynamics analyses of CLDN15 pore size and charge selectivity

2023-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Claudin-15 (CLDN15) molecules form channels that directly regulate cation and water transport. In the gastrointestinal tract, this transport indirectly impacts nutrient absorption. However, the mechanisms governing ion transport through these channels remain poorly understood. We addressed this question by building on our previous cell culture studies and all atom molecular dynamic simulation mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22de428f-9373-514d-99f8-87708615019a
DOI: 10.1101/2023.08.16.553400

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular dynamics analyses of CLDN15 pore size and charge selectivityDOI 10.1101/2023.08.16.553400Read

Molecular dynamics analyses of CLDN15 pore size and charge selectivity.Semantic proximity Read

The Impact of Pathogenic and Artificial Mutations on Claudin-5 Selectivity from Molecular Dynamics SimulationsSemantic proximity Read

A multi-pore model of the blood-brain barrier tight junction strands recapitulates the permeability features of wild-type and mutant claudin-5Semantic proximity Read

A multi-pore model of the blood-brain barrier tight junction strands recapitulates the permeability features of wild-type and mutant claudin-5.Semantic proximity Read

Molecular Simulations Meet Personalized Medicine. The Mechanism of Action of ClC-5 Antiporter and the Origin of Dent’s DiseaseSemantic proximity Read

Molecular basis of claudin-17 anion selectivity.Semantic proximity Read

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K <sup>+</sup> channel TMEM175Semantic proximity Read

Structural and Energetic Basis of Ca2+-Selective Permeation in the TRPV5 Channel.Semantic proximity Read

Claudins create charge-selective channels in the paracellular pathway between epithelial cells.Semantic proximity Read

Mechanistic Elucidation of CLIC1 Membrane Insertion via Structural and Dynamic ModulationSemantic proximity Read

Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscsSemantic proximity Read

Molecular dynamics of the pathogenic KCNQ2 variant G256W reveal mechanisms of channel dysfunction in epileptic encephalopathySemantic proximity Read