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Article

Claudins create charge-selective channels in the paracellular pathway between epithelial cells.

American journal of physiology. Cell physiology - 1 Jul 2002

Colegio Oscar R, Van Itallie Christina M, McCrea Heather J, Rahner Christoph, Anderson James Melvin

Abstract excerpt

Epithelia separate tissue spaces by regulating the passage of ions, solutes, and water through both the transcellular and paracellular pathways. Paracellular permeability is defined by intercellular tight junctions, which vary widely among tissues with respect to solute flux, electrical resistance, and ionic charge selectivity. To test the hypothesis that members of the claudin family of tight junction proteins...

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Identifiers

PMID: 12055082
DOI: 10.1152/ajpcell.00038.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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