Article
Molecular dynamics analyses of CLDN15 pore size and charge selectivity.
The Journal of general physiology - 2 Mar 2026
McGuinness Sarah, Li Pan, Li Ye, Fuladi Shadi, Konar Sukanya, Sajjadi Samaneh, Sidahmed Mohammed, Li Yueying, Shen Le, Khalili-Araghi Fatemeh, Weber Christopher R
Abstract excerpt
Claudin-15 (CLDN15) molecules form channels that directly regulate cation and water transport. In the gastrointestinal tract, this transport indirectly impacts nutrient absorption. However, the mechanisms governing ion transport through these channels remain poorly understood. We addressed this question by building on our previous cell culture studies and an all-atom molecular dynamics simulation model of CLDN15....
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