Article

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K <sup>+</sup> channel TMEM175

2021-11-06

Abstract excerpt

Structures of the human lysosomal K + channel TMEM175 in open and closed states revealed a novel architecture lacking the canonical K + selectivity filter motif present in previously known K + channel structures. A hydrophobic constriction composed of four isoleucine residues was resolved in the pore and proposed to serve as the gate in the closed state, and to confer ion selectivity in the open state. Here, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de8a2551-fd00-5231-87ab-95be7316db3d
DOI: 10.1101/2021.11.05.467414

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K <sup>+</sup> channel TMEM175DOI 10.1101/2021.11.05.467414Read

Proton selective conductance and gating of lysosomal cation channel TMEM175Semantic proximity Read

From Selective Permeation to Physiology in Potassium Channels.Semantic proximity Read

Unraveling pH Regulation of TMEM175, an Endolysosomal Cation Channel With a Role in Parkinson's Disease.Semantic proximity Read

Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel.Semantic proximity Read

K+ channel selectivity depends on kinetic as well as thermodynamic factors.Semantic proximity Read

A single residue deletion in the barley HKT1;5 P189 variant restores plasma membrane localisation but not Na+ conductance.Semantic proximity Read

Molecular dynamics analyses of CLDN15 pore size and charge selectivitySemantic proximity Read

Extracellular K <sup>+</sup> modulates the pore conformations of Cys-loop receptor anion channelsSemantic proximity Read

Structure of the human volume regulated anion channelSemantic proximity Read

A negative-hydrated constriction zone is revealed in the active state of the Hv1 channel.Semantic proximity Read

Molecular dynamics analyses of CLDN15 pore size and charge selectivity.Semantic proximity Read

Structure of the human volume regulated anion channel.Semantic proximity Read