Article

Molecular Simulations Meet Personalized Medicine. The Mechanism of Action of ClC-5 Antiporter and the Origin of Dent’s Disease

2024-11-08

Abstract excerpt

<h4>ABSTRACT</h4> ClC-5 is a Cl−/H+ antiporter crucial for the homeostasis of the entire organism, and whose functional deficiencies cause pathologies such as Dent’s disease, a rare genetic disorder that can have lethal consequences. While the clinical aspects of the pathology are known, its molecular basis is elusive, which hampers the development of potential therapies. We present here a systematic study, where...

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Literature Corpus work: 610f66be-deb2-5f30-aeb8-132c046de4b9
DOI: 10.1101/2024.11.06.622245

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