Article
Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.
Aging cell - 1 Apr 2015
MacRae Sheila L, Zhang Quanwei, Lemetre Christophe, Seim Inge, Calder Robert B, Hoeijmakers Jan, Suh Yousin, Gladyshev Vadim N, Seluanov Andrei, Gorbunova Vera, Vijg Jan, Zhang Zhengdong D
Abstract excerpt
Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeared to be strongly conserved, with copy number variation in only four genes. Interestingly, we found NMR to have a...
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