Article

A systematic approach identifies p53-DREAM target genes associated with blood or brain abnormalities

2023-06-24

Abstract excerpt

p53 is mainly known as a tumor suppressor, but mouse models revealed that increased p53 activity may cause bone marrow failure, through mechanisms that likely include gene repression mediated by the p53-DREAM pathway. Here we designed a systematic approach to identify p53-DREAM targets whose repression might contribute to abnormal hematopoiesis. We used gene ontology to analyze transcriptomic changes associated wi...

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Identifiers and source

Literature Corpus work: 55443657-6f43-579f-bf7d-3554b66e5b97
DOI: 10.1101/2023.06.21.545932

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