Endogenous Processes Underlying Clock-Like Mutational Signatures.

Abstract excerpt

Wellcome Trust scientists have shown that "mutational signatures" in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single-base substitution (SBS) signatures, with SBS1, SBS5, and SBS40 linked to aging and present in normal tissues. SBS1 results from cytosine demethylation,...

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