Article

Inactivation of the DREAM complex mimics the molecular benefits of sleep

2024-06-30

Abstract excerpt

Circadian clock disruption and lack of sleep impair organismal health, but remedies remain elusive. Here, we used multi-omics, molecular and functional assays in C. elegans , human retinal cells and mouse brain to identify the DREAM complex as a conserved mediator of sleep and clock benefits at the cellular level. We show that DREAM abundance is under circadian control with high levels seen during wakefulness. DR...

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Literature Corpus work: 018f696f-d718-5889-b890-9c9695e001a0
DOI: 10.1101/2024.06.26.600859

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