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Article

Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia.

Biological psychiatry - 1 Apr 2024

Akkouh Ibrahim A, Ueland Thor, Szabo Attila, Hughes Timothy, Smeland Olav B, Andreassen Ole A, Osete Jordi Requena, Djurovic Srdjan

Abstract excerpt

BACKGROUND: Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate the molecular mechanisms contributing to SCZ risk in a disease-relevant model of the prenatal human brain. METHODS: We generated induced pluripotent stem cell-derived organoids, termed human...

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Identifiers

PMID: 37661009
DOI: 10.1016/j.biopsych.2023.08.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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