Article

Development positions malignant cellular states but does not explain their diversification

2026-06-01

Abstract excerpt

Epithelial cancers are often described as aberrant reactivations of embryonic or tissue-forming programs, but whether malignant cellular-state diversification is actually constrained by developmental trajectories remains unclear. Here, we present a quantitative framework to test this idea in pancreatic ductal adenocarcinoma (PDAC). Using representation learning on large-scale single-cell data, we build a reference...

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Literature Corpus work: 2281971a-dba9-502b-8aff-efd0d3c34127
DOI: 10.64898/2026.05.28.728220

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