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Article

High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer.

The Journal of pathology - 1 Jan 2024

Michiels Ellis, Madhloum Hediel, Van Lint Silke, Messaoudi Nouredin, Kunda Rastislav, Martens Sandrina, Giron Philippe, Olsen Catharina, Lefesvre Pierre, Dusetti Nelson, El Mohajer Leila, Tomasini Richard, Hawinkels Lukas Jac, Ahsayni Farah, Nicolle Rémy, Arsenijevic Tatjana, Bouchart Christelle, Van Laethem Jean-Luc, Rooman Ilse

Abstract excerpt

A 'classical' and a 'basal-like' subtype of pancreatic cancer have been reported, with differential expression of GATA6 and different dosages of mutant KRAS. We established in situ detection of KRAS point mutations and mRNA panels for the consensus subtypes aiming to project these findings to paraffin-embedded clinical tumour samples for spatial quantitative analysis. We unveiled that, next to inter-patient and...

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PMID: 37842959
DOI: 10.1002/path.6212

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