Article

Unsupervised Identification of Cancer Attractor States through the Lens of Embryonic Origin and Cancer Hallmarks

2026-01-14

Abstract excerpt

<h4>Background</h4> Oncogenesis is a highly intricate process characterized by the transition of normal cells into aberrant biological attractor states. These states emerge from the non-random combinatorial interactions between inherent lineage-specific programs, governed by Gene Regulatory Networks (GRNs), and acquired somatic mutations. While the hallmarks of cancer provide a functional framework for transforma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55b1ffde-df8e-5928-902a-c813addcb29f
DOI: 10.64898/2026.01.13.699215

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unsupervised Identification of Cancer Attractor States through the Lens of Embryonic Origin and Cancer HallmarksDOI 10.64898/2026.01.13.699215Read

Biomolecular events in cancer revealed by attractor metagenes.Semantic proximity Read

Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective.Semantic proximity Read

Hallmarks of cancer—the new testamentSemantic proximity Read

Predictive genomics: a cancer hallmark network framework for predicting tumor clinical phenotypes using genome sequencing data.Semantic proximity Read

Learning the cellular origins of cancer using single-cell chromatin landscapesSemantic proximity Read

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.Semantic proximity Read

PathMethy: an interpretable AI framework for cancer origin tracing based on DNA methylationSemantic proximity Read

Pan-cancer landscape of epigenetic factor expression predicts tumor outcomeSemantic proximity Read

Genomic determinants of metastatic organotropism and dissemination tempo across 3,368 lung cancersSemantic proximity Read

Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer.Semantic proximity Read

SPARK: A Systems-level Computational Framework for Reconstructing Transcriptomic State Organisation in Lung AdenocarcinomaSemantic proximity Read

Development positions malignant cellular states but does not explain their diversificationSemantic proximity Read