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Extra-lineage tissue programs define the transcription states of human pancreatic cancer

2026-05-04

Abstract excerpt

Cancers acquire alternate transcriptional states as they evolve, but the origins, timing and determinants of this plasticity are poorly understood in many tumours. We investigated the transcriptional states of pancreatic cancer by integrating ∼1000 tumour-enriched genomes and transcriptomes from 464 patients combined with scRNA-seq, multiome profiling, and spatial proteomics. Four epithelial states covering the sp...

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Identifiers and source

Literature Corpus work
e0691a16-1ae1-53d8-a59d-c44c0b657d2d
DOI
10.64898/2026.04.29.721655
Open publication

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Extra-lineage tissue programs define the transcription states of human pancreatic cancerDOI 10.64898/2026.04.29.721655
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