Article

Transcriptional signals of dedifferentiation in human cancer

2022-11-28

Abstract excerpt

As normal cells transform into cancers, their cell state changes (or “dedifferentiates”), which may drive cancer cells into a stem-like or more primordial, foetal or embryonic cell state. Here, we used single cell atlases to study dedifferentiation in transcriptional terms across a wide spectrum of adult and childhood cancers. At the level of the whole transcriptome, we find that adult cancers rarely return to an...

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Literature Corpus work: eff9db6e-5a8c-5f2a-b188-4ca2a2b341a9
DOI: 10.1101/2022.11.28.518191

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