Article

Perturbation-guided mapping of colorectal cancer cell states to causal mechanisms

2026-03-05

Abstract excerpt

Colorectal cancer (CRC) cell atlases have refined descriptive maps of tumour ecosystems, yet cross-sample integration often obscures disease-relevant patient-specific variation and remains largely correlative, limiting insight into the mechanisms and state transitions that drive progression and treatment response. Here, we develop a continual learning framework to construct a comparative single-cell CRC atlas span...

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Literature Corpus work: 502e4a1b-2788-5691-b297-ee539bc36807
DOI: 10.64898/2026.03.03.708171

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