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Article

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

1 Dec 2021

Abstract excerpt

Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of their drivers, stability, and relationship to therapeutic response is limited. To examine these attributes systematically, we profiled metastatic biopsies and matched organoid models at single-cell resolution. In vivo, we identify a new intermediate PDAC transcriptional cell state and uncover...

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PMID: 34890551
DOI: 10.1016/j.cell.2021.11.017

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