Article
Precancerous neoplastic cells can move through the pancreatic ductal system.
Nature - 1 Sept 2018
Makohon-Moore Alvin P, Matsukuma Karen, Zhang Ming, Reiter Johannes G, Gerold Jeffrey M, Jiao Yuchen, Sikkema Lisa, Attiyeh Marc A, Yachida Shinichi, Sandone Corinne, Hruban Ralph H, Klimstra David S, Papadopoulos Nickolas, Nowak Martin A, Kinzler Kenneth W, Vogelstein Bert, Iacobuzio-Donahue Christine A
Abstract excerpt
Most adult carcinomas develop from noninvasive precursor lesions, a progression that is supported by genetic analysis. However, the evolutionary and genetic relationships among co-existing lesions are unclear. Here we analysed the somatic variants of pancreatic cancers and precursor lesions sampled from distinct regions of the same pancreas. After inferring evolutionary relationships, we found that the ancestral...
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