Article

Developmental Deconvolution for Classification of Cancer Origin

2021-11-20

Abstract excerpt

Cancer is a disease manifesting in abrogation of developmental programs, and malignancies are named based on their cell or tissue of origin. However, a systematic atlas of tumor origins is lacking. Here we map the single cell organogenesis of 56 developmental trajectories to the transcriptomes of over 10,000 tumors across 33 cancer types. We use this map to deconvolute individual tumors into their constituent deve...

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Literature Corpus work: 4cf3b072-345d-54b7-a1c1-310cb0d633d2
DOI: 10.1101/2021.11.15.21266314

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