Article

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

2020-02-18

Abstract excerpt

<title>Abstract</title> <p>Background: Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer’s disease (AD) in elderly populations. While dietary supplementation of B-vitamins is a generally effective method to lower homocysteine levels, there is little if any benefit to cognition. In the context of amyloid pathology, dietary-induced HHcy is known to enha...

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Literature Corpus work: f41e0aea-2caf-5ffb-a5b6-aa811f335411
DOI: 10.21203/rs.2.23797/v1

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