Article

„APP family member dimeric complexes are formed predominantly in synaptic compartments“

2022-09-16

Abstract excerpt

The amyloid precursor protein (APP), a key player in Alzheime’s disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2. They share similar structures, form homo- and heterotypic dimers and exhibit overlapping functions. We investigated complex formation of the APP family members via two inducible dimerization systems, the FKBP-rapamycin based dimerization as well as cysteine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2239cef2-ab4c-52f7-9831-1e592dd6bf13
DOI: 10.1101/2022.09.13.507759

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

„APP family member dimeric complexes are formed predominantly in synaptic compartments“DOI 10.1101/2022.09.13.507759Read

Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid AggregatesSemantic proximity Read

Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.Semantic proximity Read

Role of ANXA2, HSP90AA1 and PTK2B in synaptic homeostasis through microglial cells in the human entorhinal cortex in Alzheimer’s diseaseSemantic proximity Read

The phosphoS655 Alzheimer’s Amyloid Precursor Protein (APP) interactome in neuronal differentiationSemantic proximity Read

Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APPSemantic proximity Read

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domainsSemantic proximity Read

Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting Protein<i>In Vivo</i>That Modulates Amyloidogenic Processing<i>In Vitro</i>Semantic proximity Read

Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain.Semantic proximity Read

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid β fibril formationSemantic proximity Read

Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.Semantic proximity Read

Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activitySemantic proximity Read

β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals.Semantic proximity Read