Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid β fibril formation

11 Aug 2021

Abstract excerpt

, accelerates the formation of fibrils with unique polymorphs and their deposition into amyloid plaques in the affected brain.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Nuclear Receptors and Signaling
Share to Prion Diseases and Protein Misfolding

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34380771
DOI: 10.1126/scitranslmed.abc6184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid β fibril formationPMID 34380771Read ↗

Mutations in APP and their role in beta-amyloid deposition.Semantic proximity Read ↗

The amyloid precursor protein: beyond amyloid.Semantic proximity Read ↗

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s DiseaseSemantic proximity Read ↗

The Uppsala APP Mutation Promotes Wild-Type Amyloid-β Aggregation and Deposition In Vivo.Semantic proximity Read ↗

APP physiological and pathophysiological functions: insights from animal models.Semantic proximity Read ↗

Cellular functions of the amyloid precursor protein from development to dementia.Semantic proximity Read ↗

The human β-amyloid precursor protein: biomolecular and epigenetic aspectsSemantic proximity Read ↗

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.Semantic proximity Read ↗

Presenilin function in APP processing.Semantic proximity Read ↗

Truncating mutations in APP cause a distinct neurological phenotype.Semantic proximity Read ↗

Amyloid β-peptide and Alzheimer's disease.Semantic proximity Read ↗

APP Osaka Mutation in Familial Alzheimer's Disease-Its Discovery, Phenotypes, and Mechanism of Recessive Inheritance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.